Metastasis detection is now possible using OncoImmunin's unique
fluorogenic substrates to assay the protease activities associated with metastasis of
malignant cells. Examples of current reagents for metastasis analysis are CaDiLux® for the
detection of cathepsin D, ElastoLux® for the detection of elastase, and MetastaLuxTM for detection of collagenolytic activity.
As with OncoImmunins caspase substrates, CaDiLux® and ElastoLux®
cross intact plasma membranes and are therefore able to detect
intracellular proteolytic activites in live cells. In contrast, MetastaLuxTM, which contains a sequence found in collagen, is immobilized and can detect cells utilizing collagenolytic activity as they move through a 3-dimensional matrix.